Isaiah 10:9–11 refers to the destruction of Carchemish by the Assyrian king Sargon II in 717 BC. 2 Chronicles 35:20–25 records the death of Josiah, king of Judah, in 609 BC at Megiddo when Josiah tried to prevent Necho, king of Egypt, from going to Carchemish to help the Assyrians against the Babylonians. And Jeremiah 46:2 alludes to the final defeat of the Assyrians and their Egyptian allies at Carchemish by soon-to-be Babylonian king Nebuchadnezzar in 605 BC.
For more, see: The New York Times (off-site link).